Gosset Amino acid in stratum corneum Overview
Amino acids in the stratum corneum refer to free amino acids that accumulate in the outermost layer of the epidermis as major components of the natural moisturizing factor (NMF). These amino acids—such as glycine, proline, lysine, arginine, alanine, asparagine, glutamine, and histidine—are critical for maintaining skin hydration, regulating barrier function, and preserving the structural integrity of the skin. Their concentration correlates with skin health, moisture retention, and age-related changes in skin barrier properties. Unlike classic molecular drug targets, these amino acids are not enzymes, receptors, transporters, or direct drug targets, but are biological effectors important in skin physiology and are supplemented by topical products to support skin health and treat dry skin or aging.
Mechanism of Action
Not relevant as target is not a receptor/enzyme. In skincare: topical delivery of amino acids increases skin hydration, supports barrier repair, and may enhance production of natural moisturizing factors.
Biological Functions
Disease Associations
Safety Considerations
- None specific to the presence of amino acids in the stratum corneum.
Interacting Drugs
Associated Biomarkers
| Biomarker |
|---|
| Levels of specific amino acids in stratum corneum (e.g., alanine, arginine, asparagine, glutamine, glycine, histidine) are biomarkers for skin hydration status and aging |