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Aminotransferase

Molecular classification: Enzyme

Overview

Aminotransferases are vital enzymes mediating reversible transfer of amino groups between amino acids and keto acids—a central process in protein metabolism—with alanine aminotransferase serving as both a key metabolic enzyme and sensitive clinical biomarker for hepatic injury due to its abundance in hepatocytes.

Other names: Transaminase

Biological functions

Amino acid metabolismNitrogen metabolismGluconeogenesisSynthesis of amino acidsDegradation of amino acids

Disease associations

Liver diseaseHepatocellular injuryAlcohol-related liver diseaseNonalcoholic fatty liver disease (NAFLD)Viral hepatitisCeliac diseaseMuscle disordersThyroid conditions

Safety considerations

Drug toxicityHepatocellular injury

Interacting drugs

Acetaminophen

1 more in the full profile.

Biomarkers

Elevated serum ALT levelsAST/ALT ratio

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