Ammonia (Nitrogen) Metabolism

Ammonia metabolism refers to the biological processes by which nitrogen, primarily in the form of ammonia (NH₃) or ammonium ion (NH₄⁺), is produced, assimilated, transported, and excreted in living organisms. This system is central to nitrogen balance and detoxification. It encompasses various pathways like nitrogen fixation, ammonia assimilation, and the urea cycle. While not a direct drug target itself, specific enzymes within these pathways are targeted by drugs to manage disorders like hyperammonemia.

Other names

Nitrogen MetabolismAmmonia AssimilationUrea Cycle

Varies depending on the specific enzyme or step targeted within the pathway; examples include ammonia scavenging, inhibition of urease-producing bacteria, and alternative pathway activation.