AMPA glutamate receptor (AMPAR)

The AMPA glutamate receptor (AMPAR) is an ionotropic glutamate receptor responsible for mediating fast excitatory neurotransmission in the central nervous system. It is a tetrameric complex composed of GluA1-GluA4 subunits. Activation by glutamate or synthetic agonists leads to the opening of a cation channel, primarily permeable to sodium, resulting in neuronal depolarization. Its function is crucial for learning, memory, and synaptic plasticity.

Other names

AMPA receptorα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

Binding of glutamate or other agonists opens the ion channel, allowing influx of Na+ and, in some cases, Ca2+, leading to neuronal depolarization and excitation.