Glycogen Debranching Enzyme (None)

Glycogen debranching enzyme (GDE) is a crucial enzyme in glycogen metabolism, responsible for the breakdown of branched glycogen molecules to release glucose. It is a multifunctional, bifunctional enzyme with two distinct catalytic activities: transferase and glucosidase. GDE works alongside glycogen phosphorylase to mobilize glucose from glycogen stores by transferring three glucose residues from the branch to another chain and cleaving the remaining α-1,6 linkage to release free glucose. Deficiency or mutations in AGL cause glycogen storage disease type III (GSDIII), characterized by hepatomegaly, hypoglycemia, and myopathy.

Other names

GDEAmylo-α-1,6-GlucosidaseOligo-1,4-α-GlucanotransferaseAGL

Inhibition of glycogen debranching enzyme activity (GDE) to modulate glucose release from glycogen stores. Currently, there are no known drugs that target GDE. The mechanism would be inhibition to slow down glycogen breakdown in certain diseases.