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Amyloid beta peptide 1-42 (Aβ(1-42))
- Target
- Aβ(1-42)
- Molecular classification
- Peptide, Intrinsically Disordered Protein
01
Overview
Amyloid beta peptide 1-42 (Aβ(1-42)) is a 42-amino acid peptide that is a major component of amyloid plaques in Alzheimer's disease. It exists as an intrinsically disordered protein under physiological conditions but aggregates into neurotoxic oligomers and fibrils. Aβ(1-42) is a key target for therapeutic intervention and a biomarker for diagnosis and progression monitoring.
- Other names
- Amyloid beta 42Abeta 1-42Aβ42AB1-42
02
Mechanism of action
Inhibition of aggregation; disruption of fibril formation; reduction of plaque burden
03
Biological functions
Synaptic function regulation (physiological, low concentrations)Neurotoxicity (pathological, high concentrations)Amyloid plaque formationOligomer formation
04
Disease associations
Alzheimer's DiseaseNeurodegenerative disease
05
Safety considerations
Potential for off-target effects due to structural similarity with other proteins.Immunogenicity of anti-Aβ antibodies.Lack of clinical efficacy in some trials targeting Aβ.
06
Biomarkers
Amyloid plaques (imaging)Soluble Aβ(1-42) levels
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