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Amyloid Beta Peptide Aggregation
- Molecular classification
- Peptide aggregation, Protein aggregation
01
Overview
Amyloid beta (Aβ) peptide aggregation refers to the process by which Aβ peptides self-associate into various aggregated forms, including oligomers, protofibrils, fibrils, and plaques. This process is a hallmark of Alzheimer's disease (AD), with the accumulation of Aβ aggregates, particularly in the form of amyloid plaques, contributing to neurotoxicity and cognitive decline. Small soluble oligomers are considered the most neurotoxic species. Inhibiting or modulating amyloid beta peptide aggregation is a major therapeutic strategy for AD.
- Other names
- Aβ aggregationAmyloid plaque formationAbeta aggregationAβ oligomerization
02
Mechanism of action
Inhibition of Aβ aggregation; promotion of Aβ clearance
03
Biological functions
Protein misfoldingSelf-assemblyNeurotoxicityPlaque formation
04
Disease associations
Alzheimer's diseaseCerebral amyloid angiopathy
05
Safety considerations
Potential for off-target effectsRisk of ARIA (Amyloid-Related Imaging Abnormalities) with antibody-based therapiesNeed for early intervention before extensive plaque formation
06
Interacting drugs
Small molecules that prevent oligomerization/fibrillization
2 more in the full profile.
07
Biomarkers
Aβ levels in cerebrospinal fluid (CSF)Aβ PET imaging
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