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Target intelligence / Profile preview
Amyloid-beta protein (Aβ) pathological aggregates (Aβ)
- Target
- Aβ
- Molecular classification
- Amyloidogenic protein, Protein aggregate
01
Overview
- Other names
- Beta-amyloidA-betaAmyloid-beta peptideAβ42Aβ40Amyloid plaquesSenile plaques
02
Mechanism of action
Passive immunization via monoclonal antibodies to promote clearance of plaques and oligomers; inhibition of BACE1 or gamma-secretase to reduce peptide production; anti-aggregation agents to prevent fibril formation.
03
Biological functions
Synaptic plasticity regulationAntimicrobial activityNeurotoxicity
04
Disease associations
Alzheimer's diseaseCerebral amyloid angiopathyInclusion body myositis
05
Safety considerations
Amyloid-related imaging abnormalities}
06
Interacting drugs
Aducanumab
6 more in the full profile.
07
Biomarkers
CSF Aβ42/Aβ40 ratioAmyloid PET imagingPlasma Aβ42/Aβ40 ratio
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