Gosset Molecular Classification
Protein Aggregate, Pathological deposit
Other Names
Amyloid plaques, Amyloid fibrils, Amyloid aggregates
Disease Roles
Amyloid Deposit Overview
Amyloid deposits are abnormal aggregates of proteins that accumulate in tissues and organs, disrupting their normal function. These deposits are a hallmark of a group of diseases known as amyloidoses, which can affect multiple organ systems including the heart, kidneys, liver, spleen, nervous system, and digestive tract. Amyloids are characterized by their fibrillar morphology and a cross-β-sheet secondary structure. Deposition disrupts tissue architecture and function and may lead to organ failure.
Mechanism of Action
Biological Functions
Protein aggregation
Tissue disruption
Induction of inflammation
Induction of fibrosis
Disease Associations
Amyloidosis
Alzheimer's Disease
AL amyloidosis
AA amyloidosis
ATTR amyloidosis
Neurodegenerative disease
Cardiovascular disease
Renal failure
Safety Considerations
- Organ damage
- Tissue disruption
- Inflammation
- Fibrosis
Associated Biomarkers
| Biomarker |
|---|
| Amyloid-beta plaques (Alzheimer's) |
| Immunoglobulin light chains (AL amyloidosis) |
| Serum amyloid A (AA amyloidosis) |
| Transthyretin (ATTR amyloidosis) |