Target intelligence / Profile preview

Androgen Receptor (N-terminal Domain) (AR NTD)

Target: AR NTD
Molecular classification: Transcription factor, Nuclear receptor

Overview

The androgen receptor’s n-terminal domain plays a central role in regulating gene expression by recruiting coactivators through its intrinsically disordered yet functionally critical structure. Its unique properties make it an important therapeutic target—particularly for advanced prostate cancers resistant to conventional anti-androgen therapies that act on other domains.

Other names: Amino-terminal domainTranscriptional regulation domainAR N-terminal domain

Mechanism of action

Inhibition of AR NTD-mediated transcriptional activity

Biological functions

Transcriptional activationProtein-protein interactionGene regulationCoregulator recruitmentDimerization

Disease associations

Prostate cancerAndrogen-related disorders

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