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Angiogenesis (Endothelial Cord Formation)
- Molecular classification
- Extracellular matrix remodeling, Cell adhesion, Growth factor signaling
01
Overview
Angiogenesis is the physiological process by which new blood vessels form from pre-existing vessels. Endothelial cord (or tube) formation is a key in vitro model used to study this process, particularly the reorganization and differentiation of endothelial cells into capillary-like structures. This assay mimics the early stages of angiogenesis, where endothelial cells align, migrate, and form tubular networks when exposed to angiogenic stimuli.
- Other names
- Endothelial cord formationTube formation assayNeovascularizationVascular remodeling
02
Mechanism of action
Inhibition of endothelial cell proliferation, migration, or tube formation
03
Biological functions
New blood vessel formationTissue repairEmbryonic developmentCell migrationCell proliferationCell differentiation
04
Disease associations
Cancer progression/metastasisDiabetic retinopathyRheumatoid arthritisPsoriasisAtherosclerosisStrokeImpaired wound healingChronic inflammation
05
Safety considerations
Impaired wound healingHypertensionThrombotic eventsProteinuria
06
Interacting drugs
VEGF inhibitors (e.g., Bevacizumab, Sunitinib, Sorafenib)
3 more in the full profile.
07
Biomarkers
VEGF levelsAngiogenic factors in serumCirculating endothelial cells
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