Angiogenesis (secretion of angiogenic factors)

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. The secretion of angiogenic factors initiates a cascade involving the release of chemical signals from hypoxic or injured tissues, binding to receptors on endothelial cells, leading to endothelial cell activation, proliferation, migration, and differentiation. This process is essential for normal growth, development, wound healing, and tissue repair, but also plays a critical role in pathological conditions such as cancer. Therapeutic strategies targeting this pathway include angiogenesis inhibitors that block key molecules like VEGF or its receptor signaling pathways.

Other names

NeovascularizationTumor angiogenesisBlood vessel formation

Inhibition of angiogenic factor secretion, receptor binding, or downstream signaling pathways to prevent new blood vessel formation.