Gosset Angiopoietin 1 Overview
Angiopoietin 1 (Ang1) is a secreted glycoprotein and a member of the angiopoietin family of growth factors. It is a critical regulator of angiogenesis, promoting the organization and maturation of newly formed vessels and maintaining quiescence and structural integrity in adult vasculature. Ang1 enhances endothelial cell survival by inhibiting apoptosis and stimulates endothelial cell migration, proliferation, and motility during vessel formation/remodeling. It suppresses plasma leakage by improving endothelial monolayer integrity and inhibits vascular inflammation. Ang1 primarily acts through the Tie2 receptor, an endothelial-specific receptor tyrosine kinase. Loss of Ang1 function leads to severe defects in heart development and abnormal vasculature, highlighting its essential role in developmental angiogenesis.
Mechanism of Action
Ang1 binds to and activates the Tie2 receptor tyrosine kinase, promoting endothelial cell survival, migration, and vessel stabilization.
Biological Functions
Disease Associations
Safety Considerations
- Dysregulation may contribute to pathological conditions involving abnormal angiogenesis or increased vascular permeability.