Angiopoietin-1 (ANGPT1)

Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that plays a crucial role in vascular development, angiogenesis, and the maintenance of blood vessel stability and integrity. It primarily signals through the Tie2 receptor on endothelial cells, activating pathways that promote cell survival, inhibit apoptosis, and regulate vascular permeability and inflammation. While ANGPT1 shows promise as a therapeutic target for diseases involving abnormal vascular function, careful consideration must be given to potential off-target effects such as pathological neovascularization.

Other names

Ang1

ANGPT1 binds to its receptor, Tie2, leading to Tie2 phosphorylation and activation of downstream signaling pathways such as PI3K/Akt. This promotes cell survival and vessel stabilization.