Angiopoietin-1; Angiopoietin-2 (Ang-1; Ang-2)

Angiopoietin-1 and Angiopoietin-2 are secreted glycoproteins that bind to and modulate the activity of the Tie2 receptor on endothelial cells, controlling blood vessel formation, stabilization (by Angiopoietin-1) and destabilization (by Angiopoietin-2). Angiopoietin-1 promotes vessel maturation, endothelial survival, and integrity. Angiopoietin-2 acts as a context-dependent antagonist or partial agonist, promoting vascular permeability and regression particularly under pathological conditions such as cancer and inflammation. The Angiopoietins interact with VEGF signaling, and their balance is critical in maintaining vascular homeostasis. Both are prominent therapeutic targets in cancer, retinal/vascular disease, and chronic inflammatory settings. Measuring their circulating levels provides prognostic information in oncology and cardiovascular disease.

Other names

Angiopoietin 1 (Angpt1)Angiopoietin 2 (Angpt2)ANGPT1ANGPT2Ang-1Ang-2

Antagonism or blockade of Ang-2 (restores vascular stability, limits tumor growth and inflammation) Tie2 agonism/activation by Ang-1 (promotes vessel maturation and stabilization) Dual inhibition of Ang-2 and VEGF (synergistic antiangiogenic effect)