Gosset Angiopoietin-2 Overview
Angiopoietin-2 (ANGPT2) is a secreted glycoprotein that plays complex roles in angiogenesis and inflammation. It belongs to the angiopoietin family, crucial for vascular and lymphatic systems. It is a 496 amino acid protein with a secretion signal peptide, coiled-coil domain, and fibrinogen-like domain; the mature form is 478 amino acids. It forms multimers (dimers, trimers, tetramers, pentamers) under non-reducing conditions. Ang2 binds the Tie2 receptor with similar affinity to Ang1. Unlike Ang1, Ang2 can function as a Tie2 antagonist or agonist depending on its multimerization state. It regulates vascular remodeling, promotes or induces endothelial cell death/vessel regression, cooperates in lymphatic development, mediates leukocyte adhesion during inflammation, and regulates endothelial permeability. Ang2 is widely expressed during development but restricted postnatally to highly angiogenic tissues like placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells stored in Weibel-Palade bodies. Unlike Ang1, Ang2 acts in an autocrine manner and its expression is highly regulated, triggered by inflammatory mediators, hypoxia, and cancer. Ang2 is implicated in several pathological conditions including cancer (promoting tumor cell invasion), ischemic tissue, and vascular regression. It also promotes neuronal differentiation and migration. Ang2 is considered a potential therapeutic target for various vascular-related diseases.
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Safety Considerations
No safety concerns listed