Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Angiopoietin-2 (Ang-2)
- Target
- Ang-2
- Molecular classification
- Secreted glycoprotein, Growth factor
01
Overview
Angiopoietin-2 (Ang-2) is a secreted glycoprotein and growth factor that plays a central role in the regulation of angiogenesis and inflammation. It primarily acts as an antagonist of the Tie2 receptor, blocking the stabilizing effects of Angiopoietin-1 (Ang1) on blood vessels, but can act as a weak agonist under certain conditions. Ang-2 modulates vascular permeability, endothelial cell migration and proliferation, and blood vessel destabilization/remodeling. Its dysregulation contributes significantly to pathological processes involving abnormal blood vessel growth or permeability such as cancer progression and inflammatory diseases.
- Other names
- ANGPT2
02
Mechanism of action
Inhibition of Ang-2 and VEGF-A binding to their native receptors (e.g., Tie2)
03
Biological functions
Regulation of angiogenesisModulation of vascular permeabilityEndothelial cell migration and proliferationBlood vessel destabilization/remodeling
04
Disease associations
CancerSepsisAcute lung injuryInflammation
05
Safety considerations
Potential for vascular leakageOff-target effects on angiogenesisPotential to disrupt normal vascular homeostasis
06
Interacting drugs
Faricimab
07
Biomarkers
Elevated Ang-2 levels in cancerElevated Ang-2 levels in sepsisElevated Ang-2 levels in acute lung injury
Beyond the preview
Go deeper on Angiopoietin-2 (Ang-2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Angiopoietin-2 (Ang-2).