Gosset Molecular Classification
Angiopoietin-like proteins (ANGPTLs), Secreted glycoprotein
Other Names
ANGPTL3
Disease Roles
Angiopoietin-like 3 protein Overview
Angiopoietin-like 3 protein (ANGPTL3) is a secreted glycoprotein primarily expressed in the liver. It plays a central role in lipid metabolism by inhibiting lipoprotein lipase (LPL) and endothelial lipase (EL), thereby modulating triglyceride, LDL-C, and HDL-C levels. It is also involved in angiogenesis through interactions with integrins on endothelial cells. ANGPTL3 is a promising molecular target for reducing CHD risk.
Mechanism of Action
Inhibition of LPL and EL, leading to increased plasma triglyceride, LDL-C, and HDL-C levels. Also interacts with integrins to promote cell adhesion and migration.
Biological Functions
Regulation of lipid metabolism
Inhibition of lipoprotein lipase (LPL)
Inhibition of endothelial lipase (EL)
Regulation of angiogenesis
Cell adhesion
Cell migration
Disease Associations
Cardiovascular disease
Coronary artery disease
Familial combined hypolipidemia
Colorectal cancer
Liver metastasis
Safety Considerations
No safety concerns listed
Associated Biomarkers
| Biomarker |
|---|
| Plasma ANGPTL3 levels |