Gosset Angiopoietin-like protein 8 Overview
Angiopoietin-like protein 8 (ANGPTL8), also known as betatrophin, is a secreted glycoprotein that regulates serum triglyceride levels by modulating lipoprotein lipase (LPL) activity. It acts as an inhibitor of LPL and forms complexes with other angiopoietin-like proteins, such as ANGPTL3 and ANGPTL4, to regulate lipid metabolism. While there has been interest in its potential role in promoting pancreatic beta-cell proliferation and insulin release, this remains controversial. Dysregulation of ANGPTL8 has been associated with metabolic disorders such as liver steatosis and potentially type II diabetes. It has also shown potential therapeutic effects in experimental models of Adriamycin-induced cardiomyopathy.
Mechanism of Action
Inhibits lipoprotein lipase (LPL) activity by forming complexes with ANGPTL3 or ANGPTL4, promoting LPL dissociation into inactive monomers.
Biological Functions
Disease Associations
Safety Considerations
- Controversial role in beta-cell proliferation in humans.
- Dysregulation associated with metabolic diseases.