Angiostatin receptor (multiple binding partners including ATP synthase and Angiomotin) (Angiostatin Target)

This target refers to the molecular complex and signaling pathways through which Angiostatin and related anti-angiogenic agents exert their effects on endothelial cells. It is characterized by its ability to inhibit endothelial cell proliferation and migration while simultaneously downregulating the expression of urokinase-type plasminogen activator (uPA). Key identified components of this target system include surface-expressed ATP synthase, which Angiostatin inhibits to trigger endothelial apoptosis, and Angiomotin, which regulates cell motility. In disease states, particularly cancer, this target is exploited to suppress tumor-induced neovascularization and metastasis by preventing the degradation of the extracellular matrix. Therapeutic intervention at this target aims to starve tumors of their blood supply and limit their invasive potential.

Other names

Angiostatin binding proteinEndothelial cell proliferation inhibitor targetuPA expression regulatorATP synthase (surface-expressed)AngiomotinAMOT

Inhibition of endothelial cell surface ATP synthase to deplete intracellular ATP; binding to Angiomotin to disrupt cell migration; downregulation of uPA expression to prevent matrix degradation.