Angiotensin-converting enzyme (N-terminal domain) (None)

The N-terminal domain of angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a critical role in the renin-angiotensin system. While ACE has two catalytic domains (N- and C-), the N-domain exhibits distinct substrate specificity, preferentially cleaving peptides like AcSDKP, angiotensin-(1–7), and amyloid β-protein(1–42). Its function extends beyond blood pressure regulation, influencing peptide metabolism in various tissues. Understanding its unique role is important for developing selective inhibitors with potential therapeutic applications in hypertension and neurodegenerative diseases.

Inhibition of angiotensin-converting enzyme activity