Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Angiotensin-converting enzyme 2 (ACE2)
- Target
- ACE2
- Molecular classification
- Enzyme, Type I transmembrane glycoprotein, Zinc metallopeptidase, Receptor
01
Overview
Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein and zinc metallopeptidase that plays a crucial role in the renin–angiotensin–aldosterone system (RAAS), regulating blood pressure, fluid balance, and vascular resistance. It acts as a carboxypeptidase, converting angiotensin II to angiotensin 1-7, thereby counterbalancing the effects of ACE. ACE2 also serves as the entry receptor for coronaviruses like SARS-CoV-2. Altered ACE2 expression or function is implicated in cardiovascular, pulmonary, metabolic, and infectious diseases, making it a potential therapeutic target.
02
Mechanism of action
Modulation of ACE2 activity (e.g., upregulation, inhibition)
03
Biological functions
Carboxypeptidase activityRegulation of blood pressureRegulation of fluid balanceRegulation of vascular resistanceAngiotensin II to Angiotensin 1-7 conversionAngiotensin I to Angiotensin 1-9 conversionHydrolysis of apelin and des-Arg9-bradykininIntestinal neutral amino acid transportReceptor for coronaviruses (SARS-CoV, SARS-CoV-2, HCoV-NL63)
04
Disease associations
Cardiovascular diseases (Hypertension, Heart failure, Myocardial infarction)Pulmonary diseases (Pulmonary hypertension, Acute lung injury)Metabolic disorders (Diabetes-related cardiovascular complications)Infectious diseases (COVID-19, SARS)
05
Safety considerations
Potential for ACE2 downregulation during viral infectionComplex and context-dependent roles in various diseasesPossible unintended consequences of ACE2 modulation
Beyond the preview
Go deeper on Angiotensin-converting enzyme 2 (ACE2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Angiotensin-converting enzyme 2 (ACE2).