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Target intelligence / Profile preview
Angiotensin II (Ang II)
- Target
- Ang II
- Molecular classification
- Peptide hormone, RAAS component
01
Overview
Angiotensin II is a peptide hormone and the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It plays a critical role in regulating blood pressure, fluid balance, and various physiological functions. It is not a therapeutic target itself, but rather a key component of a system that is targeted by drugs.
02
Mechanism of action
Agonist of angiotensin II receptors (AT1 and AT2)
03
Biological functions
VasoconstrictionSodium and water retentionAldosterone release stimulationAntidiuretic hormone (ADH) release stimulationThirst regulationNeuronal function regulationInflammation mediationVascular permeability increase
04
Disease associations
HypertensionCardiovascular diseasesInflammationSeptic shock
05
Safety considerations
Elevated levels contribute to hypertension and cardiovascular diseasesOverstimulation of AT1 receptor can lead to adverse cardiovascular effects
06
Interacting drugs
Angiotensin II
2 more in the full profile.
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