Molecular Classification
Peptide hormone, RAAS component
Disease Roles
HypertensionCardiovascular diseasesInflammation

Angiotensin II Overview

Angiotensin II is a peptide hormone and the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It plays a critical role in regulating blood pressure, fluid balance, and various physiological functions. It is not a therapeutic target itself, but rather a key component of a system that is targeted by drugs.

Mechanism of Action

Agonist of angiotensin II receptors (AT1 and AT2)

Biological Functions

Vasoconstriction
Sodium and water retention
Aldosterone release stimulation
Antidiuretic hormone (ADH) release stimulation
Thirst regulation
Neuronal function regulation
Inflammation mediation
Vascular permeability increase

Disease Associations

Hypertension
Cardiovascular diseases
Inflammation
Septic shock

Safety Considerations

  • Elevated levels contribute to hypertension and cardiovascular diseases
  • Overstimulation of AT1 receptor can lead to adverse cardiovascular effects

Interacting Drugs

Angiotensin II
Angiotensin receptor blockers (ARBs)
ACE inhibitors