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Target intelligence / Profile preview
Angiotensin II Type-1 Receptor (AT1)
- Target
- AT1
- Molecular classification
- G protein-coupled receptor, GPCR, Rhodopsin-like receptor
01
Overview
The Angiotensin II type-1 receptor (AT1) is a G protein-coupled receptor (GPCR) that mediates most of the known physiological and pathophysiological effects of angiotensin II. It plays a crucial role in cardiovascular regulation, blood pressure control, and fluid homeostasis. It is a primary therapeutic target for hypertension and related cardiovascular diseases. Drugs targeting AT1, such as Angiotensin Receptor Blockers (ARBs), are widely used clinically.
- Other names
- Angiotensin receptor type 1AT1 receptorAGTR1
02
Mechanism of action
Selective antagonism of the Angiotensin II Type-1 Receptor
03
Biological functions
VasoconstrictionAldosterone synthesis/secretionIncreased vasopressin secretionCardiac hypertrophyRegulation of blood pressureSignal transductionVascular smooth muscle cell proliferationVascular smooth muscle cell migrationVascular smooth muscle cell remodelingRenal tubular sodium reuptake
04
Disease associations
HypertensionDiabetic nephropathyCongestive heart failureCardiovascular diseaseMyocardial infarctionLeft ventricular remodeling
05
Safety considerations
HypotensionHyperkalemiaRenal dysfunctionAngioedemaPregnancy contraindication
06
Interacting drugs
Losartan
1 more in the full profile.
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