Anillin, actin binding protein (ANLN)

Anillin (ANLN) is a conserved cytoskeletal scaffold protein crucial for cell division, especially cytokinesis, by organizing the contractile ring through interactions with F-actin, myosin II, and RhoA[2][3][4][1]. ANLN is present in the nucleus during interphase and in the contractile ring during cytokinesis. Recent research highlights its role in the nucleus, where ANLN directly interacts with RNA polymerase II to form transcriptional condensates, influencing transcription initiation and enhancer activity, and promoting cancer cell proliferation[1]. ANLN’s dysfunction can lead to abnormal cell division and is implicated as an oncogenic driver in diverse cancers. Its actin-binding and scaffolding activities are essential for maintaining proper cytoskeletal architecture and cell morphology[2][3][4][1]. Drugs targeting ANLN-mediated condensate formation (e.g., THZ1) represent a novel therapeutic strategy in cancer, though safety concerns remain due to its fundamental cell division functions.

Other names

AnillinANLNANILLINScrapsscraFSGS8

Inhibition of ANLN-mediated transcriptional condensate formation (e.g., THZ1 disrupts ANLN–Pol II clustering and associated gene expression)