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Target intelligence / Profile preview
Annexin A10 (ANXA10) mRNA (ANXA10)
- Target
- ANXA10
- Molecular classification
- Annexin family, Calcium-binding protein, Phospholipid-binding protein
01
Overview
Annexin A10 (ANXA10) is a member of the annexin family of calcium-dependent phospholipid-binding proteins, characterized by its unique expression in the gastric mucosa and its role in cell cycle regulation (UniProt P50995, Human Protein Atlas). It is a highly specific biomarker for the serrated pathway of colorectal cancer and is frequently overexpressed in pancreatic ductal adenocarcinoma, where it promotes tumor cell proliferation and migration (PMID: 25344771, PMID: 28637501). Conversely, its expression is often lost in hepatocellular carcinoma, indicating a complex, context-specific role in oncogenesis (PMID: 24333715). As a therapeutic target, ANXA10 mRNA is being explored for knockdown via RNA interference (siRNA) to treat overexpressing malignancies (PMID: 30217950). Potential safety concerns for targeting ANXA10 include off-target effects of RNA-based therapies and possible adverse impacts on the normal gastric epithelium where ANXA10 is physiologically abundant.
- Other names
- Annexin-14ANX14Annexin A10
02
Mechanism of action
RNA interference
03
Biological functions
Calcium ion bindingPhospholipid bindingCell cycle regulationSignal transductionCell differentiation
04
Disease associations
Colorectal cancerPancreatic ductal adenocarcinomaGastric cancerHepatocellular carcinomaBladder cancer
05
Safety considerations
Off-target effects of RNA-based therapiesPotential gastrointestinal toxicity due to high physiological expression in gastric mucosaLimited understanding of systemic physiological roles
06
Interacting drugs
Experimental siRNA
07
Biomarkers
ANXA10 mRNA expressionANXA10 protein expression (IHC)
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