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Target intelligence / Profile preview
Anoctamin 1 (ANO1)
- Target
- ANO1
- Molecular classification
- Ion channel, Transmembrane protein, Calcium-activated chloride channel
01
Overview
Anoctamin 1 (ANO1), also known as TMEM16A, is a voltage-gated, calcium-activated anion channel primarily conducting chloride ions. It plays critical roles in transepithelial anion transport, smooth muscle contraction, pacemaker activity, cell proliferation and migration, secretion, and neuronal excitation. Overexpression or dysregulation is linked to cancer progression and other diseases.
- Other names
- TMEM16ADOG1ORAOV2TAOS-2
02
Mechanism of action
Calcium-activated chloride channel modulation
03
Biological functions
Transepithelial anion transportSmooth muscle contractionPacemaker activityCell proliferationCell migrationSecretionNeuronal excitationIodide transmembrane transporter activityLigand-gated monoatomic ion channel activity
04
Disease associations
CancerPolycystic kidney diseasePainAnxiety
05
Safety considerations
Potential for off-target effects due to widespread expressionDysregulation can lead to tumorigenesis
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