Molecular Classification
Ion channel, Transmembrane protein, Calcium-activated chloride channel
Other Names
TMEM16A, DOG1, ORAOV2, TAOS-2
Disease Roles
CancerPolycystic kidney diseasePain

Anoctamin 1 Overview

Anoctamin 1 (ANO1), also known as TMEM16A, is a voltage-gated, calcium-activated anion channel primarily conducting chloride ions. It plays critical roles in transepithelial anion transport, smooth muscle contraction, pacemaker activity, cell proliferation and migration, secretion, and neuronal excitation. Overexpression or dysregulation is linked to cancer progression and other diseases.

Mechanism of Action

Calcium-activated chloride channel modulation

Biological Functions

Transepithelial anion transport
Smooth muscle contraction
Pacemaker activity
Cell proliferation
Cell migration
Secretion
Neuronal excitation
Iodide transmembrane transporter activity
Ligand-gated monoatomic ion channel activity

Disease Associations

Cancer
Polycystic kidney disease
Pain
Anxiety

Safety Considerations

  • Potential for off-target effects due to widespread expression
  • Dysregulation can lead to tumorigenesis