Gosset Antibody-Dependent Cellular Phagocytosis Overview
Antibody-dependent cellular phagocytosis (ADCP) is an immunological mechanism in which effector cells of the immune system, primarily professional phagocytes such as monocytes, macrophages, neutrophils, and eosinophils, recognize and engulf target cells or particles that have been opsonized (coated) with antibodies. This process is a critical component of the body's defense against pathogens and also plays a significant role in the therapeutic action of certain monoclonal antibodies used to treat cancer.
Mechanism of Action
ADCP is a mechanism of action for monoclonal antibodies, where the antibody binds to a target on a cell (e.g., tumor cell), and the Fc region of the antibody is recognized by Fc receptors on effector cells (e.g., macrophages), leading to phagocytosis and destruction of the target cell.
Biological Functions
Disease Associations
Safety Considerations
- Potential for off-target effects of antibodies
- Evasion mechanisms developed by pathogens
- Technical challenges in ADCP assays