Gosset Molecular Classification
Enzyme, Mycolyltransferase, Fibronectin-binding protein
Disease Roles
Antigen 85 Complex B Overview
Antigen 85B (Ag85B) is an abundant secreted enzyme crucial for Mycobacterium tuberculosis cell wall construction via mycolic acid transfer reactions; it binds host fibronectin aiding infection establishment; it provokes robust immune responses making it valuable both diagnostically and as a vaccine/drug target against TB.
Mechanism of Action
Inhibition of mycolyltransferase activity disrupts cell wall synthesis
Biological Functions
Cell wall biogenesis
Mycolic acid transfer
Cell adhesion
Immune response
Disease Associations
Infection
Tuberculosis
Safety Considerations
No safety concerns listed
Associated Biomarkers
| Biomarker |
|---|
| T-cell proliferation |
| IFN-gamma secretion |