Antioxidant enzyme ()

Antioxidant enzyme Overview

"Antioxidant enzyme activity" is not a single molecular target but rather refers collectively to the catalytic functions performed by several distinct families of enzymes that protect cells from oxidative damage. The most prominent antioxidant enzymes include superoxide dismutases (SOD), catalases (CAT), glutathione peroxidases (GPX), and peroxiredoxins. These enzymes work together in cellular defense systems to detoxify reactive oxygen species such as superoxide anion (O_2^-) and hydrogen peroxide (H_2O_2), thereby preventing cellular injury caused by oxidative stress[3][4][5]. Each family has unique substrates and mechanisms—for example, SOD converts superoxide into hydrogen peroxide, which is then further reduced to water by CAT or GPX. These activities are essential for maintaining redox homeostasis in both health and disease states. However, "antioxidant enzyme activity" itself does not refer to a specific protein or gene product but rather an aggregate function shared among multiple related but distinct molecular entities. Because "Antioxidant enzyme activity" is not a single molecule/receptor/target but instead describes the collective action of several different proteins with similar biological roles, it should not be considered a canonical therapeutic target on its own. Instead, each member—such as "Superoxide dismutase," "Catalase," or "Glutathione peroxidase"—should be treated individually for structured data purposes[3][4]. **Note:** For structured databases requiring unique targets with defined sequences/structures/functions/mechanisms/drug interactions/etc., use the names and properties of individual antioxidant enzymes rather than this umbrella term.

Mechanism of Action

Catalysis of the conversion of ROS to less reactive molecules (e.g., superoxide to hydrogen peroxide by SOD; hydrogen peroxide to water by catalase or glutathione peroxidase)

Biological Functions

Safety Considerations

Interacting Drugs

Associated Biomarkers