Gosset Antioxidant Enzyme System Overview
The antioxidant enzyme system is a group of endogenous enzymes that protect cells from oxidative stress by neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS). Key enzymes include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), thioredoxin reductase (TrxR) & peroxiredoxin (Prx), among others. These systems are crucial in preventing oxidative damage implicated in many human diseases, including aging, cardiovascular disorders, neurodegeneration, diabetes complications, cancer progression, and inflammatory conditions. Optimal activity depends on trace minerals, and impaired activity increases susceptibility to oxidative-stress-related diseases.
Mechanism of Action
Sequential conversion of reactive oxygen species into less harmful substances like water and oxygen.
Biological Functions
Disease Associations
Safety Considerations
- Compromised antioxidant defenses due to micronutrient deficiencies (Selenium, Iron, Copper, Zinc, Manganese).
- Dysregulation of enzyme expression or activity leading to oxidative stress.
- Potential for pro-oxidant effects at high concentrations of certain antioxidants.