Gosset Antipruritic Overview
"Antipruritic" is not the name of a specific molecule or therapeutic target, but rather an umbrella term for any agent—drug or substance—that relieves itching (pruritus). These agents can belong to various pharmacological classes such as antihistamines, local anesthetics, opioid modulators, immunosuppressants, and more. The mechanisms by which they relieve itch are diverse and depend on their molecular targets—for example: - Histamine H1 antagonists, which block histamine-mediated itch, - κ-opioid receptor agonists, which modulate neural pathways involved in pruritus, - Immunomodulators, which reduce inflammation contributing to itch[1][5][6]. Because "antipruritic" does not refer to any one molecule/receptor/enzyme/transporter/etc., it should not be treated as a canonical therapeutic target. Instead, it describes the intended effect of many different drugs acting via distinct mechanisms. If you require structured information about actual molecular targets relevant for antipruritics—such as "Histamine H1 receptor," "Neurokinin 1 receptor," "κ-opioid receptor," etc.—please specify one of those targets instead[1][7].
Mechanism of Action
Not applicable for the term itself. Mechanisms vary by drug class: Histamine H1 antagonism; κ-opioid receptor agonism/μ-opioid antagonism; Sodium channel blockade; Immune modulation.
Biological Functions
No biological function data available
Disease Associations
No disease associations available
Safety Considerations
- Not applicable to the term itself; safety concerns depend on specific antipruritic agents used.