Molecular Classification
Apolipoprotein, Mutated Protein
Other Names
ApoA-I Milano, ETC-216, MDCO-216, apoAI-Milano
Disease Roles
Cardiovascular diseaseAtherosclerosisAlzheimer's Disease (potential)

Apolipoprotein A-I Milano Overview

Apolipoprotein A-I Milano is a naturally occurring mutated variant of apolipoprotein A1 (ApoA-I). The mutation (R173C) enhances reverse cholesterol transport and reduces atherosclerosis despite low HDL-cholesterol levels. Recombinant forms are under development as therapies to regress vascular plaques.

Mechanism of Action

Promotes cholesterol efflux from tissues, facilitates reverse cholesterol transport, reduces vascular plaque burden.

Biological Functions

Reverse cholesterol transport
Lecithin-cholesterol acyltransferase (LCAT) cofactor
Cholesterol efflux
Anti-atherosclerotic activity
Immune modulation
Anti-inflammatory

Disease Associations

Cardiovascular disease
Atherosclerosis
Alzheimer's Disease (potential)

Safety Considerations

  • Potential immunogenicity of recombinant forms
  • Long-term effects of altered lipid profiles

Interacting Drugs

Recombinant ApoA-I Milano (ETC-216, MDCO-216)
Phospholipids (used in formulation)

Associated Biomarkers

Biomarker
HDL-cholesterol levels
Triglyceride levels
Carotid artery thickness
Coronary plaque volume