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Apolipoprotein A-I Milano (None)
- Target
- None
- Molecular classification
- Apolipoprotein, Mutated Protein
01
Overview
Apolipoprotein A-I Milano is a naturally occurring mutated variant of apolipoprotein A1 (ApoA-I). The mutation (R173C) enhances reverse cholesterol transport and reduces atherosclerosis despite low HDL-cholesterol levels. Recombinant forms are under development as therapies to regress vascular plaques.
- Other names
- ApoA-I MilanoETC-216MDCO-216apoAI-Milano
02
Mechanism of action
Promotes cholesterol efflux from tissues, facilitates reverse cholesterol transport, reduces vascular plaque burden.
03
Biological functions
Reverse cholesterol transportLecithin-cholesterol acyltransferase (LCAT) cofactorCholesterol effluxAnti-atherosclerotic activityImmune modulationAnti-inflammatory
04
Disease associations
Cardiovascular diseaseAtherosclerosisAlzheimer's Disease (potential)
05
Safety considerations
Potential immunogenicity of recombinant formsLong-term effects of altered lipid profiles
06
Interacting drugs
Recombinant ApoA-I Milano (ETC-216, MDCO-216)
1 more in the full profile.
07
Biomarkers
HDL-cholesterol levelsTriglyceride levelsCarotid artery thicknessCoronary plaque volume
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