Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Arabinofuranosyltransferase
- Molecular classification
- Enzyme, Glycosyltransferase, Transferase
01
Overview
Arabinofuranosyltransferases are a class of enzymes (transferases) that catalyze the transfer of arabinose residues in the polymerization of arabinan and arabinogalactan—key components of the mycobacterial cell wall. These enzymes are essential for building the complex cell wall structure in mycobacteria, such as *Mycobacterium tuberculosis*. Specific enzymes include EmbA, EmbB, EmbC, and AftA, which are crucial for synthesizing arabinogalactan (AG) and lipoarabinomannan (LAM). They are validated drug targets; ethambutol inhibits these enzymes, blocking cell wall biosynthesis.
- Other names
- Arabinose transferaseEmbAEmbBEmbCAftA
02
Mechanism of action
Inhibition of arabinosyl transferases (EmbA, EmbB, EmbC), blocking cell wall biosynthesis.
03
Biological functions
Cell wall biosynthesisPolymerization of arabinanPolymerization of arabinogalactanLipoarabinomannan (LAM) synthesisArabinogalactan (AG) synthesis
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Drug resistance (mutations in Emb proteins)Overexpression affecting enzyme activity
06
Interacting drugs
Ethambutol
Beyond the preview
Go deeper on Arabinofuranosyltransferase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Arabinofuranosyltransferase.