Arachidonate 15-lipoxygenase (ALOX15) mRNA (ALOX15 mRNA)

Arachidonate 15-lipoxygenase (ALOX15) mRNA is the messenger RNA transcript encoding the ALOX15 enzyme, a non-heme iron-containing dioxygenase that plays a central role in the metabolism of polyunsaturated fatty acids (NIH, 2023). The enzyme, also known as 15-lipoxygenase-1, catalyzes the conversion of arachidonic acid and linoleic acid into bioactive lipid mediators such as 15-HETE and 13-HODE, which are involved in signaling pathways related to inflammation and ferroptosis (Frontiers in Immunology, 2024). ALOX15 is highly expressed in specific cell types, including eosinophils, macrophages, and airway epithelial cells, and its dysregulation is implicated in diseases such as asthma, chronic rhinosinusitis, and idiopathic pulmonary fibrosis (NIH, 2026; Nature Genetics, 2019). Therapeutic strategies targeting ALOX15 mRNA, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), are being explored to reduce enzyme expression and mitigate pro-inflammatory and pro-fibrotic effects (NIH, 2026). However, because ALOX15 also contributes to the synthesis of specialized pro-resolving mediators (SPMs) like lipoxins, its inhibition presents a complex challenge in balancing the suppression of disease-driving pathways with the maintenance of the body's natural inflammation resolution mechanisms (JCI, 2015).

Other names

15-LOX-1 mRNA15-Lipoxygenase-1 mRNALOG15 mRNAArachidonate 12/15-lipoxygenase mRNA

RNA interference (RNAi) mediated degradation of mRNA; Antisense-mediated knockdown; Translational inhibition via 3'-UTR binding proteins.