Gosset Arachidonic Acid Pathway Overview
The arachidonic acid (AA) pathway refers to the metabolic processes involving arachidonic acid, a polyunsaturated omega-6 fatty acid that is a key component of cell membranes. AA is released from membrane phospholipids, primarily by phospholipase A2 (PLA2). Once liberated, AA serves as the precursor for eicosanoids, which include prostaglandins, thromboxanes, leukotrienes, and epoxyeicosatrienoic acids. These metabolites play crucial roles in inflammation, cell fate decisions, vascular tone regulation, and tissue development. The pathway is a major target for anti-inflammatory drugs, and modulation of this pathway has therapeutic potential for various conditions.
Mechanism of Action
Inhibition of COX enzymes, leading to reduced production of prostaglandins and thromboxanes.
Biological Functions
Disease Associations
Safety Considerations
- Gastrointestinal issues (NSAIDs)
- Cardiovascular risks (COX-2 selective inhibitors)
- Potential for off-target effects due to the broad involvement of eicosanoids in various physiological processes.