Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP5)

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 (AGAP5) is a predicted human protein encoded by the AGAP5 gene[1][6]. It is described as a putative GTPase-activating protein (GAP), likely involved in intracellular signaling by activating the GTPase activity of small GTP-binding proteins[1][2][6][7]. AGAP5 contains a GTPase domain, ankyrin repeat motifs, and a pleckstrin homology (PH) domain, consistent with roles in protein-protein interactions and possibly membrane association[1][2][4][6]. The gene is a member of the centaurin-gamma-like family, with AGAP4 noted as a paralog[1]. No current data links AGAP5 to direct roles in disease, nor are there drugs or clinical interventions that act via this protein. Its function is inferred from domain structure and sequence homology rather than direct experimental characterization[6][2][5][1][7]. If you require additional structural, tissue expression, or interaction data on AGAP5, refer to resources such as UniProt (A6NIR3), Human Protein Atlas, and GeneCards[1][4][6].

Other names

AGAP-5Centaurin-gamma-like family member 2CTGLF2Em:AC073389.1arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5centaurin, gamma-like family, member 2