Arf-GAP with GTPase, ankyrin repeat and PH domain-containing protein 4 (AGAP4)

Arf-GAP with GTPase, ankyrin repeat and PH domain-containing protein 4 (AGAP4) is a member of the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family, containing characteristic ankyrin repeat and pleckstrin homology (PH) domains[3][1]. AGAP4 is predicted to enable GTPase activator activity, and may participate in regulating small GTPase-mediated signal transduction, especially by modulating Arf GTPases, which are critical for vesicular trafficking in cells[3][4][1]. It belongs to the centaurin gamma-like protein family and has paralogs such as AGAP5 and AGAP6[2][3]. AGAP4 has not been identified as a direct drug target, nor is there evidence for interacting drugs or mechanisms of action, but its altered expression is potentially linked to cellular responses to low-dose radiation exposure and to benign tumors in irradiated individuals, supporting its evaluation as a possible biomarker for radiation-induced biological effects and nonmalignant tumorigenesis[1]. Its precise physiological or pathological roles remain to be further clarified, and no established safety concerns or therapeutic challenges have been reported[1][3].

Other names

AGAP-4AGAP8AGAP-8MRIP2CTGLF1CTGLF5Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4ArfGAP with GTPase domain, ankyrin repeat and PH domain 8Centaurin-gamma-like family member 1Centaurin-gamma-like family member 5