ArfGAP with GTPase domain, ankyrin repeat, and PH domain 1 pseudogene

The ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 pseudogene (ENSG00000249351, also known as LOC112268475) is classified as a **pseudogene**, meaning it is a non-coding genomic DNA sequence homologous to a known gene but generally considered non-functional—it does not encode a functional protein[1][7]. While it shares sequence similarity to the *ArfGAP with GTPase domain, ankyrin repeat and PH domain 1* (AGAP1) gene, which is involved in membrane trafficking and cytoskeleton dynamics, the pseudogene itself does not have demonstrated protein product, biological function, disease association, or relevance as a drug target[1][7]. This gene is annotated as a member of the centaurin-gamma-like family pseudogenes and is not regarded as a therapeutic target or biomarker. Any references to “AGAP1” functions or therapeutic targeting pertain to the protein-coding *AGAP1* gene, not this pseudogene. **Note:** - The entry is **not a valid therapeutic target** because it is classified as a pseudogene, not a protein-coding gene or receptor[1][7]. - It should not be used in a pharmaceutical or therapeutic context; there are no drugs, mechanisms, biomarkers, or safety concerns associated specifically with this pseudogene. - If you intended the functional gene AGAP1, refer to “ArfGAP with GTPase domain, ankyrin repeat and PH domain 1” (Ensembl: ENSG00000157985, UniProt: Q9UPQ3), which encodes a GTPase-activating protein for ARF1/ARF5 involved in vesicle trafficking[3][6][8].

Other names

LOC112268475ENSG00000249351AGAP1 pseudogeneAGAP7P (distinct from functional paralogs)Centaurin-gamma-like family member 4 pseudogene