ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 (AGAP11)

AGAP11, annotated as "ArfGAP with GTPase domain, ankyrin repeat and PH domain 11," is classified as a non-coding RNA (ncRNA) gene and not as a protein-coding gene, despite its name suggesting a possible functional protein. Although its name groups it with ArfGAP family members (proteins involved in GTPase regulation and vesicular trafficking), current evidence indicates AGAP11 does not encode a functional protein and is primarily classified under the ncRNA class[1][3]. Functional annotation data only predict possible GTPase activator activity, but this is based on its sequence similarity, not experimental validation[1]. There are no known molecular, biological, or pharmacological targets or disease associations for AGAP11, and it should not be considered a therapeutic target. Key points: - AGAP11 is a non-coding RNA gene, not a functional protein-coding gene. - The name is potentially misleading; it is not a validated member of the druggable ArfGAP protein family. - No established biological functions, disease relevance, or pharmacological data exist for AGAP11 at this time[1][3].

Other names

AGAP11KIAA1975AGAP-11Centaurin-gamma-like protein KIAA1975