ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1)

ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1) is a large multifunctional protein containing ArfGAP, RhoGAP, ankyrin repeats, SAM, and multiple pleckstrin homology (PH) domains[1][4]. It functions as a phosphoinositide-activated GTPase-activating protein (GAP), regulating both Arf and Rho family small GTPases, with a role in actin cytoskeleton remodeling, intracellular trafficking, and the assembly of actin-rich structures such as podosomes and sealing zones in osteoclasts[1][2][4]. ARAP1 is essential for the regulated trafficking of lysosomal membrane proteins and maintenance of proper bone resorption, and alterations in its activity are linked to bone, metabolic, and retinal diseases[1][2][6]. It acts as a molecular bridge between F-actin dynamics and membrane trafficking, affecting cell shape, movement, and specialized membrane domains[2][4]. Multiple alternative transcripts and isoforms exist, and homologs are found in mammalian species.

Other names

CENTD2KIAA0782Centaurin-delta-2Cnt-d2ARF-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1centaurin, delta 2