Gosset Molecular Classification
Enzyme, Hydrolase
Other Names
Arginine dihydrolase, Citrulline iminase, L-arginine deiminase, L-arginine iminohydrolase
Disease Roles
Arginine deiminase Overview
Arginine deiminase (ADI) is an enzyme that catalyzes the hydrolysis of L-arginine to L-citrulline and ammonia. It plays a key role in arginine catabolism in bacteria and has been studied as an anti-cancer agent due to its ability to deplete arginine in tumors that cannot synthesize it.
Mechanism of Action
Depletes extracellular arginine, depriving argininosuccinate synthetase-deficient tumors of this essential amino acid.
Biological Functions
Arginine and proline metabolism
Energy generation
pH regulation
Disease Associations
Cancer
Infection
Safety Considerations
- Potential for immune response against the enzyme
Associated Biomarkers
| Biomarker |
|---|
| Argininosuccinate synthetase deficiency |
| Argininosuccinate lyase deficiency |