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AS01E Adjuvant (AS01E)
- Target
- AS01E
- Molecular classification
- Adjuvant, Liposome-based formulation, TLR4 agonist (MPL), Saponin (QS-21)
01
Overview
AS01E is a liposome-based vaccine adjuvant system containing MPL (a TLR4 agonist) and QS-21 (a saponin). It enhances immune responses by activating APCs, promoting T cell priming, and stimulating antibody production, leading to increased vaccine efficacy. It is used in vaccines against diseases such as malaria, herpes zoster, tuberculosis, and RSV.
- Other names
- MPL/QS-21 liposome adjuvantAS01MPLQS-21
02
Mechanism of action
AS01E activates antigen-presenting cells (APCs), particularly dendritic cells, through MPL's TLR4 agonism and QS-21's immune-enhancing properties. This leads to enhanced antigen presentation, T cell priming, and B cell activation, resulting in strong Th1-biased cellular and humoral immune responses.
03
Biological functions
Immune response enhancementInnate immune system activationAdaptive immune system stimulationAntigen presentationT cell primingB cell activationTh1 polarization
04
Disease associations
Vaccine developmentMalariaHerpes zoster/shinglesTuberculosisRespiratory syncytial virus (RSV)
05
Safety considerations
Mild-to-moderate local or systemic adverse reactionsInjection site reactions
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