Gosset Molecular Classification
Metabolic Pathway
Other Names
Vitamin C Metabolism, Ascorbate Metabolism, L-Ascorbic Acid Metabolism
Disease Roles
Ascorbic Acid Metabolism Pathway Overview
The ascorbic acid metabolism pathway encompasses the biosynthesis, recycling, degradation, and transport of ascorbic acid (vitamin C). Ascorbic acid is a vital antioxidant and enzyme cofactor. While most plants and many animals can synthesize ascorbic acid endogenously, humans lack this ability, requiring dietary intake. The pathway involves several key steps including oxidation/reduction reactions to neutralize ROS, transport across cell membranes, and synthesis from precursor molecules. It plays a crucial role in maintaining cellular redox balance and supporting various physiological functions.
Mechanism of Action
N/A (Metabolic pathway, not a single target)
Biological Functions
Antioxidant Defense
Enzyme Cofactor Provision
Redox Regulation
Nutrient Metabolism
Plant Growth and Development
Photosynthetic Electron Transport Protection (Plants)
Disease Associations
Scurvy (Vitamin C Deficiency)
Cancer (Potential Role in Prevention/Treatment)
Cardiovascular Disease (Potential Role in Prevention)
Neurodegenerative Diseases (Potential Role in Prevention)
Oxidative Stress-Related Diseases
Safety Considerations
- High doses of ascorbic acid can cause gastrointestinal distress, kidney stones, and iron overload in susceptible individuals.
- Potential interactions with certain medications (e.g., warfarin).
- False positive glucose readings in some diabetes tests.
Interacting Drugs
None (Pathway itself is not directly targeted, but influences drug metabolism and efficacy)
Chelating agents (May affect ascorbate levels indirectly)
Antioxidants (Synergistic or antagonistic effects)
Associated Biomarkers
| Biomarker |
|---|
| Plasma Ascorbic Acid Levels |
| Urinary Ascorbic Acid Excretion |
| Tissue Ascorbic Acid Concentration |