Gosset Molecular Classification
Enzyme, Aminotransferase
Other Names
Aspartate transaminase, Serum glutamic oxaloacetic transaminase, SGOT, GOT, AAT
Disease Roles
Aspartate Aminotransferase Overview
Aspartate aminotransferase (AST), also known as aspartate transaminase or SGOT, is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible transfer of an α-amino group between aspartate and glutamate. It is found in high concentrations in the liver, heart, and skeletal muscle, and elevated levels in the blood can indicate damage to these tissues. Measurement of AST levels in blood is primarily used to assess liver health, but may also reflect injury to other tissues. Interpretation of AST levels requires clinical correlation and often additional testing.
Mechanism of Action
Not applicable (AST is an enzyme, not a drug target directly acted upon by drugs; drugs can influence its levels indirectly)
Biological Functions
Amino acid metabolism
Catalysis
Pyridoxal phosphate-dependent enzyme activity
Disease Associations
Liver disease
Myocardial infarction
Muscle injury
Safety Considerations
- Elevated AST levels are not specific to liver damage; further testing is needed to determine the source of the elevation
- Clinical correlation is required for interpretation of AST levels
Associated Biomarkers
| Biomarker |
|---|
| Elevated AST levels as an indicator of liver damage |
| Elevated AST levels as an indicator of myocardial infarction |
| Elevated AST levels as an indicator of muscle damage |