Aspartate Aminotransferase (AST)

Aspartate aminotransferase (AST), also known as aspartate transaminase or SGOT, is a pyridoxal phosphate-dependent enzyme that catalyzes the reversible transfer of an α-amino group between aspartate and glutamate. It is found in high concentrations in the liver, heart, and skeletal muscle, and elevated levels in the blood can indicate damage to these tissues. Measurement of AST levels in blood is primarily used to assess liver health, but may also reflect injury to other tissues. Interpretation of AST levels requires clinical correlation and often additional testing.

Other names

Aspartate transaminaseSerum glutamic oxaloacetic transaminaseSGOTGOTAAT

Not applicable (AST is an enzyme, not a drug target directly acted upon by drugs; drugs can influence its levels indirectly)