Ataxia Telangiectasia Mutated Protein (ATM)

Ataxia Telangiectasia Mutated Protein Overview

ATM is a large serine/threonine protein kinase that plays a central role in the cellular response to DNA double-strand breaks (DSBs) and other forms of cellular stress. It is best known as the product of the gene mutated in ataxia-telangiectasia, a rare autosomal recessive disorder. ATM acts as a master regulator for signal transduction following DNA damage, phosphorylating key proteins and initiating cell cycle checkpoints. Loss-of-function mutations in ATM cause ataxia-telangiectasia. Targeted inhibition of ATM has been explored as a strategy for radiosensitizing tumors during cancer therapy.

Mechanism of Action

Inhibition of ATM kinase activity, blocking downstream signaling pathways involved in DNA damage repair and cell cycle arrest.

Biological Functions

Safety Considerations

Interacting Drugs