Ataxia Telangiectasia Mutated Protein (ATM)

ATM is a large serine/threonine protein kinase that plays a central role in the cellular response to DNA double-strand breaks (DSBs) and other forms of cellular stress. It is best known as the product of the gene mutated in ataxia-telangiectasia, a rare autosomal recessive disorder. ATM acts as a master regulator for signal transduction following DNA damage, phosphorylating key proteins and initiating cell cycle checkpoints. Loss-of-function mutations in ATM cause ataxia-telangiectasia. Targeted inhibition of ATM has been explored as a strategy for radiosensitizing tumors during cancer therapy.

Inhibition of ATM kinase activity, blocking downstream signaling pathways involved in DNA damage repair and cell cycle arrest.