ATP-binding cassette sub-family C member 5 mRNA 3' untranslated region (ABCC5 mRNA 3'UTR)

The ABCC5 mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the messenger RNA encoding the ATP-binding cassette sub-family C member 5 (ABCC5) protein, also known as Multidrug Resistance-associated Protein 5 (MRP5). This region contains specific sequences that serve as binding sites for microRNAs (miRNAs) and RNA-binding proteins, which post-transcriptionally regulate ABCC5 expression by influencing mRNA stability and translation efficiency (Source: PubMed, PMID: 25605241). The ABCC5 protein itself is a transmembrane transporter that effluxes cyclic nucleotides and various chemotherapeutic agents, such as thiopurines and fluorouracil, contributing to multidrug resistance in several cancers (Source: UniProt, P33527). Targeting the ABCC5 mRNA 3'UTR with miRNA mimics or antisense oligonucleotides aims to downregulate ABCC5 protein levels, thereby increasing the intracellular concentration of drugs and overcoming resistance (Source: PubMed, PMID: 22430212). This approach is particularly relevant in oncology, where ABCC5 overexpression is linked to poor prognosis and treatment failure in breast, lung, and brain tumors. By modulating this regulatory region, researchers hope to sensitize resistant cancer cells to standard chemotherapy regimens (Source: PubMed, PMID: 25605241).

Other names

MRP5 mRNA 3'UTRMultidrug resistance-associated protein 5 mRNA 3'UTRABCC5 3'-UTRABCC5 3-prime untranslated region

Binding of microRNA mimics or antisense oligonucleotides to the 3'UTR sequence leads to mRNA degradation or inhibition of translation, thereby reducing the expression of the ABCC5 protein.