ATP-binding cassette subfamily B member 1 mRNA 3'-untranslated region (ABCB1 mRNA 3'-UTR)

The ATP-binding cassette subfamily B member 1 (ABCB1) mRNA 3'-untranslated region (3'-UTR) is a regulatory sequence located at the 3' end of the MDR1 transcript, which encodes the P-glycoprotein (P-gp) efflux transporter. This region plays a pivotal role in post-transcriptional gene regulation by serving as a docking site for microRNAs (miRNAs) and RNA-binding proteins that influence mRNA stability and translation (PMID: 25666300). In the context of oncology, the ABCB1 mRNA 3'-UTR is frequently involved in the development of multidrug resistance (MDR), as the loss of inhibitory miRNA binding can lead to the pathological overexpression of P-gp (PMID: 20145116). Therapeutic strategies targeting this region involve the use of miRNA mimics, such as miR-451 or miR-27a, and antisense oligonucleotides to suppress P-gp production and sensitize cancer cells to chemotherapy (PMID: 18337444). Beyond cancer, variations or mutations in this 3'-UTR may also influence drug disposition and response in other conditions, such as epilepsy or inflammatory bowel disease (PMID: 19118618). Despite its potential, targeting this region requires precise delivery systems to avoid disrupting the protective role of P-gp in healthy tissues like the blood-brain barrier and intestinal epithelium.

Other names

MDR1 mRNA 3'-UTRMultidrug resistance protein 1 mRNA 3'-untranslated regionP-glycoprotein mRNA 3'-UTRABCB1 3'-UTR

Binding of regulatory RNAs or antisense molecules to the 3'-UTR sequence to induce mRNA degradation or inhibit translation, thereby reducing the expression of the P-glycoprotein efflux pump.