ATP-binding cassette subfamily C member 10 (MRP7) (ABCC10)

ATP-binding cassette subfamily C member 10 (MRP7) is a member of the ABC transporter superfamily that functions as an ATP-dependent efflux pump [1, 4]. It is primarily localized to the basolateral membrane of various tissues, including the liver, kidney, and lungs [2, 5]. MRP7 is distinguished by its broad substrate specificity, transporting a wide range of chemotherapeutic agents such as taxanes, vinca alkaloids, and nucleoside analogs, as well as physiological substrates like leukotriene C4 and estradiol-17-beta-glucuronide [2, 3, 10]. In the context of oncology, the overexpression of MRP7 is a significant mechanism of multidrug resistance (MDR), as it actively extrudes anticancer drugs from tumor cells, thereby reducing their therapeutic efficacy [4, 7, 13]. Beyond its role in cancer, MRP7 has been implicated in physiological processes such as lipid metabolism and renal function [4, 8]. Pharmacological modulation of MRP7 using inhibitors like tyrosine kinase inhibitors or cepharanthine is being explored as a strategy to sensitize resistant tumors to chemotherapy [2, 5, 9].

Other names

Multidrug resistance-associated protein 7MRP7ABCC10SIMRP7EST182763

ATP-dependent efflux of xenobiotics and chemotherapeutic agents across the cell membrane to reduce intracellular accumulation [2, 4].