Gosset Molecular Classification
Enzyme, Acyltransferase
Other Names
ATP-citrate synthase, Citrate cleavage enzyme
Disease Roles
ATP citrate lyase Overview
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) into acetyl-CoA and oxaloacetate, using energy from ATP hydrolysis. This reaction provides cytosolic acetyl-CoA for fatty acid and cholesterol synthesis, and histone acetylation. It plays a key role in linking carbohydrate metabolism to lipid biosynthesis and is implicated in various diseases including cancer and metabolic disorders. ACLY is considered a therapeutic target, with potential inhibitors aimed at reducing lipid synthesis and affecting downstream cellular processes.
Mechanism of Action
Inhibition of ATP citrate lyase to reduce acetyl-CoA production and downstream lipid synthesis.
Biological Functions
Lipid biosynthesis
Cholesterol biosynthesis
Histone acetylation
Acetyl-CoA production
Disease Associations
Cancer
Metabolic Disorders
Hyperlipoproteinemia
Cardiovascular disease
Diabetes mellitus
Vascular remodeling
Immune System
Safety Considerations
- Potential metabolic disturbances due to altered lipid metabolism.
- On-target effects affecting normal cellular function.