ATP-dependent RNA helicase A (RHA)

ATP-dependent RNA helicase A Overview

ATP-dependent RNA helicase A (RHA) is an enzyme encoded by the DHX9 gene in humans. It functions as a multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction. It is capable of unwinding both RNA-RNA and RNA-DNA duplexes. This DEAD/DEAH box protein is implicated in numerous cellular processes involving alteration of RNA secondary structure, including translation initiation, splicing, and ribosome assembly. It may participate in melting of DNA:RNA hybrids that occur during transcription and may play a role in X-linked gene expression. The protein contains two copies of a double-stranded RNA-binding domain, a DEXH core domain, and an RGG box, with the RNA-binding domains and RGG box influencing and regulating RNA helicase activity. The DHX9 gene is located on the long arm (q) of chromosome 1. ATP-dependent RNA helicase A has been shown to interact with multiple proteins including AKAP8L, BRCA1, DDX17 (p72), DDX5 (p68), KHDRBS1, MIZF, NXF1, PRMT1, RELA, and SMN1.

Mechanism of Action

Biological Functions

Safety Considerations