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Target intelligence / Profile preview
ATP-sensitive potassium channel (KATP) in arterial smooth muscle (KATP)
- Target
- KATP
- Molecular classification
- Ion channel, Potassium channel, ATP-gated channel
01
Overview
The ATP-sensitive potassium channel (KATP) in arterial smooth muscle is a hetero-octameric ion channel composed of Kir6.x and SURx subunits. It couples cellular metabolism to membrane potential and vascular tone. Activation leads to vasodilation, while inhibition promotes vasoconstriction. It is implicated in cardiovascular diseases such as hypertension and diabetes-related vascular dysfunction.
- Other names
- Arterial smooth muscle KATP channelATP-sensitive potassium channelKATP channelKir6.1/SUR2B channel
02
Mechanism of action
Activation leads to vasodilation by hyperpolarizing the cell membrane; inhibition leads to vasoconstriction by depolarizing the cell membrane
03
Biological functions
Regulation of membrane potentialRegulation of vascular toneMetabolic sensingVasodilationHyperpolarization
04
Disease associations
HypertensionDiabetes-related vascular dysfunctionCardiovascular disease
05
Safety considerations
Potential for drug interactions with sulfonylureasOff-target effects of KATP channel openers
06
Interacting drugs
Sulfonylureas
1 more in the full profile.
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